It is widely acknowledged that, by the end of this century, climate change will be the dominant driver of biodiversity loss and ecosystem transformation. Australia is a unique country. Isolated from other continents for over 40 million years, its land surface exceeds 7.6 million km2, contains biomes as diverse as tropical, arid and alpine, and houses a wealth of unique flora and fauna. As with other countries around the world, Australia’s biodiversity is facing a significant threat from climate change, which, combined with other environmental pressures, presents enormous challenges for conservation. In this seminar, I discuss the Biodiversity Node, a dynamic collaboration between university researchers, government scientists, managers and policy makers, tasked with developing a research program to inform conservation objectives, strengthen decision-making and transfer knowledge to non-scientist end-users.