Bakgrunn
PhD Evolusjonsgenetikk, Universitetet i Oslo (2011).
MSc Bioteknologi, Norges miljø- og biovitenskapelige universitet (2006).
Publikasjonsliste Google scholar
Jarl Andreas Anmarkrud - Google Scholar
Emneord:
Molekylærbiologi,
Genetikk,
Metagenomikk,
Evolusjon
Publikasjoner
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Lifjeld, Jan Terje; Hernando, Miguel de Gabriel; Marcos, Benito Fuertes; Grønstøl, Gaute; Anmarkrud, Jarl Andreas & Matschiner, Michael
[Vis alle 7 forfattere av denne artikkelen]
(2023).
Rapid sperm length divergence in a polygynandrous passerine: a mechanism of cryptic speciation?
Evolution.
ISSN 0014-3820.
77(11),
s. 2352–2364.
doi:
10.1093/evolut/qpad146.
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Rekdal, Silje Larsen; Anmarkrud, Jarl Andreas; Lifjeld, Jan Terje & Johnsen, Arild
(2019).
Extra‐pair mating in a passerine bird with highly duplicated major histocompatibility complex class II: Preference for the golden mean.
Molecular Ecology.
ISSN 0962-1083.
doi:
10.1111/mec.15273.
Fulltekst i vitenarkiv
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Rekdal, Silje Larsen; Anmarkrud, Jarl Andreas; Johnsen, Arild & Lifjeld, Jan Terje
(2018).
Genotyping strategy matters when analyzing hypervariable major histocompatibility complex-Experience from a passerine bird.
Ecology and Evolution.
ISSN 2045-7758.
8(3),
s. 1680–1692.
doi:
10.1002/ece3.3757.
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Johnsen, Arild; Kearns, Anna Marika; Omland, Kevin E. & Anmarkrud, Jarl Andreas
(2017).
Sequencing of the complete mitochondrial genome of the common raven Corvus corax (Aves: Corvidae) confirms mitogenome-wide deep lineages and a paraphyletic relationship with the Chihuahuan raven C. cryptoleucus.
PLOS ONE.
ISSN 1932-6203.
12(10).
doi:
10.1371/journal.pone.0187316.
Fulltekst i vitenarkiv
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Tronstad, Rune Rose; Kummen, Martin; Holm, Kristian; Volkmann, Hilde Løland Von; Anmarkrud, Jarl Andreas & Høivik, Marte Lie
[Vis alle 13 forfattere av denne artikkelen]
(2017).
Guanylate cyclase C activation shapes the intestinal microbiota in patients with familial diarrhea and increased susceptibility for Crohn's disease.
Inflammatory Bowel Diseases.
ISSN 1078-0998.
23(10),
s. 1752–1761.
doi:
10.1097/MIB.0000000000001264.
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Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Nygård, Ståle; Vesterhus, Mette & Høivik, Marte
[Vis alle 14 forfattere av denne artikkelen]
(2016).
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls.
Gut.
ISSN 0017-5749.
66(4),
s. 611–619.
doi:
10.1136/gutjnl-2015-310500.
Vis sammendrag
Objective: Gut microbiota could influence gut, as well as hepatic and biliary immune responses. We therefore thoroughly characterised the gut microbiota in primary sclerosing cholangitis (PSC) compared with healthy controls (HC) and patients with ulcerative colitis without liver disease.
Design: We prospectively collected 543 stool samples. After a stringent exclusion process, bacterial DNA was submitted for 16S rRNA gene sequencing. PSC and HC were randomised to an exploration panel or a validation panel, and only significant results (p<0.05, QFDR<0.20) in both panels were reported, followed by a combined comparison of all samples against UC.
Results: Patients with PSC (N=85) had markedly reduced bacterial diversity compared with HC (N=263, p<0.0001), and a different global microbial composition compared with both HC (p<0.001) and UC (N=36, p<0.01). The microbiota of patients with PSC with and without IBD was similar. Twelve genera separated PSC and HC, out of which 11 were reduced in PSC. However, the Veillonella genus showed a marked increase in PSC compared with both HC (p<0.0001) and UC (p<0.02). Using receiver operating characteristic analysis, Veillonella abundance yielded an area under the curve (AUC) of 0.64 to discriminate PSC from HC, while a combination of PSC- associated genera yielded an AUC of 0.78.
Conclusions: Patients with PSC exhibited a gut microbial signature distinct from both HC and UC without liver disease, but similar in PSC with and without IBD. The Veillonella genus, which is also associated with other chronic inflammatory and fibrotic conditions, was enriched in PSC.
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Hov, Johannes Espolin Roksund; Zhong, Huanzi; Qin, Bincai; Anmarkrud, Jarl Andreas; Holm, Kristian & Franke, Andre
[Vis alle 8 forfattere av denne artikkelen]
(2015).
The influence of the autoimmunity-associated ancestral HLA haplotype AH8.1 on the human gut microbiota: A cross-sectional study.
PLOS ONE.
ISSN 1932-6203.
10:e0133804(7).
doi:
10.1371/journal.pone.0133804.
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Johnsen, Arild; Brabrand, Åge; Anmarkrud, Jarl Andreas; Bjørnstad, Gro; Pavels, Henning & Saltveit, Svein Jakob
(2014).
Impact of human-induced environmental changes on genetic structure and variability in Atlantic salmon, Salmo salar.
Fisheries Management and Ecology.
ISSN 0969-997X.
21(1),
s. 32–41.
doi:
10.1111/fme.12049.
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Næss, Sigrid; Björnsson, Einar; Anmarkrud, Jarl Andreas; Al Mamari, Said; Juran, Brian D. & Lazaridis, Konstantinos N.
[Vis alle 15 forfattere av denne artikkelen]
(2014).
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease.
Liver international (Print).
ISSN 1478-3223.
34(10),
s. 1488–1495.
doi:
10.1111/liv.12492.
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Gohli, Jostein; Anmarkrud, Jarl Andreas; Johnsen, Arild; Kleven, Oddmund; Borge, Thomas & Lifjeld, Jan Terje
(2013).
Female promicuity is positively associated with neutral and selected genetic diversity in passerine birds.
Evolution.
ISSN 0014-3820.
67(5),
s. 1406–1419.
doi:
10.1111/evo.12045.
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Anmarkrud, Jarl Andreas; Johnsen, Arild; Bachmann, Lutz & Lifjeld, Jan Terje
(2010).
Ancestral polymorphism in exon 2 of bluethroat (Luscinia svecica) MHC class II B genes.
Journal of Evolutionary Biology.
ISSN 1010-061X.
23(6),
s. 1206–1217.
doi:
10.1111/j.1420-9101.2010.01999.x.
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Canal, David; Alcaide, Miguel; Anmarkrud, Jarl Andreas & Potti, Jaime
(2010).
Towards the simplification of MHC typing protocols: targeting classical MHC class II genes in a passerine, the pied flycatcher Ficedula hypoleuca.
BMC Research Notes.
ISSN 1756-0500.
3(236).
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Anmarkrud, Jarl Andreas; Kleven, Oddmund; Bachmann, Lutz & Lifjeld, Jan Terje
(2008).
Microsatellite evolution: Mutations, sequence variation, and homoplasy in the hypervariable avian microsatellite locus HrU10.
BMC Evolutionary Biology.
ISSN 1471-2148.
8(138).
doi:
10.1186/1471-2148-8-138.
Vis sammendrag
BACKGROUND
Microsatellites are frequently used genetic markers in a wide range of applications, primarily due to their high length polymorphism levels that can easily be genotyped by fragment length analysis. However, the mode of microsatellite evolution is yet not fully understood, and the role of interrupting motifs for the stability of microsatellites remains to be explored in more detail. Here we present a sequence analysis of mutation events and a description of the structure of repeated regions in the hypervariable, pentanucleotide microsatellite locus HrU10 in barn swallows (Hirundo rustica) and tree swallows (Tachycineta bicolor).
RESULTS
In a large-scale parentage analysis in barn swallows and tree swallows, broods were screened for mutations at the HrU10 locus. In 41 cases in the barn swallows and 15 cases in the tree swallows, mutations corresponding to the loss or gain of one or two repeat units were detected. The parent and mutant offspring alleles were sequenced for 33 of these instances (26 in barn swallows and 7 in tree swallows). Replication slippage was considered the most likely mutational process. We tested the hypothesis that HrU10, a microsatellite with a wide allele size range, has an increased probability of introductions of interruptive motifs (IMs) with increasing length of the repeated region. Indeed, the number and length of the IMs was strongly positively correlated with the total length of the microsatellite. However, there was no significant correlation with the length of the longest stretch of perfectly repeated units, indicating a threshold level for the maximum length of perfectly repeated pentanucleotide motifs in stable HrU10 alleles. The combination of sequence and pedigree data revealed that 15 barn swallow mutations (58%) produced alleles that were size homoplasic to other alleles in the data set.
CONCLUSIONS
Our results give further insights into the mode of microsatellite evolution, and support the assumption of increased slippage rate with increased microsatellite length and a stabilizing effect of interrupting motifs for microsatellite regions consisting of perfect repeats. In addition, the observed extent of size homoplasy may impose a general caution against using hypervariable microsatellites in genetic diversity measures when alleles are identified by fragment length analysis only.
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Rekdal, Silje Larsen; Anmarkrud, Jarl Andreas; Lifjeld, Jan Terje & Johnsen, Arild
(2022).
MHC-based mate choice in bluethroats.
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Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Vesterhus, Mette; Høivik, Marte & Trøseid, Marius
[Vis alle 12 forfattere av denne artikkelen]
(2015).
O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
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Wittig, Michael; Anmarkrud, Jarl Andreas; Forster, Michael; Ellinghaus, Eva; Holm, Kristian & Wienbrandt, L
[Vis alle 12 forfattere av denne artikkelen]
(2013).
In solution HLA capture and high-resolution NGS-based typing method and an automated, integrated analysis framework.
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Naess, Sigrid; Anmarkrud, Jarl Andreas; Björnsson, Einar; Al Mamari, Said; Juran, Brian D. & Lazaridis, Konstantios N
[Vis alle 13 forfattere av denne artikkelen]
(2012).
HLA associations in small-duct compared with large-duct primary sclerosing cholangitis.
Hepatology.
ISSN 0270-9139.
56,
s. 1134A–1134A.
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Anmarkrud, Jarl Andreas; Kleven, Oddmund; Bachmann, Lutz & Lifjeld, Jan Terje
(2007).
The mode of microsatellite evolution revealed through pedigree analysis in barn swallow (Hirundo rustica).
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Anmarkrud, Jarl Andreas
(2011).
Evolution of genetic diversity at two hypervariable markers: a microsatellite and the MHC.
Universitetet i Oslo.
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Anmarkrud, Jarl Andreas
(2006).
Analyser av et system for regulert genuttrykk i melkesyrebakterier.
Universitet for Miljø og Biovitenskap.
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Publisert
1. sep. 2014 12:37
- Sist endret
12. apr. 2024 13:56